Neonatal Encephalopathy with Seizures (NEwS)

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Neonatal Encephalopathy with Seizures (NEwS)

Description:

Neonatal Encephalopathy with Seizures (NEwS) is an autosomal recessive disease of standard poodle puppies. Affected puppies are small and weak at birth. Cerebella from affected puppies have been found to be reduced in size. Many die in their first week of life. Those surviving past 1 week develop ataxia, a whole-body tremor. By 4 to 6 weeks of age, puppies develop severe generalized tonic-clonic seizures. None have survived to 7 weeks of age.

 

This fatal disease affects the brain of newborn puppies causing weakness, seizures, and ultimately death within a few weeks of birth.  Neonatal encephalopathy is recessive — both parents must possess the gene mutation in order to produce offspring affected by the disease.  Dogs with one copy of this gene do not show symptoms, but are carriers and can pass the gene to their offspring. It is important to test before breeding so as to avoid breeding two carriers together.

Acceptable Sample Types:

Animal Genetics accepts buccal swab, blood, and dewclaw samples for testing. Complimentary sample collection kits are available and can be ordered at test now.

This Test Is Relevant For the Following Breeds:

  • Standard Poodle

Results:

Animal Genetics offers DNA testing for Neonatal Encephalopathy with Seizures (NEWS). The genetic test verifies the presence of the recessive mutation and presents results as one of the following:

NE/NE Affected The dog carries two copies of the mutant gene and is homozygous for the MDR1 mutation. The dog will react to Ivermectin, or other listed drugs, and will always pass on a copy of the mutated gene to its offspring.
NE/n Carrier Both the normal and mutant copies of the gene detected. Some sensitivity to listed drugs can occur. Dog is a carrier for the MDR1 mutation and can pass on a copy of the defective gene to its offspring 50% 0f the time.
n/n Clear Dog tested negative for the MDR gene mutation and will not pass on the defective gene to its offspring.