K-Locus (Dominant Black)


Description:
Coat coloration is controlled by several different genes in dogs. One of these gene is referred to as "Dominant Black." The presence or absence of this gene determines if a dog can express "agouti" color patterns.

The Dominant Black gene consists of three different alleles, or variants. The first allele, which is dominant, is noted as "KB," or dominant black. The Dominant Black allele is actually a mutation that does not allow the agouti gene to be expressed. Because this mutation is dominant, a dog only needs to have one copy of the mutation to suppress the agouti locus. A dog that has one or two copies of the Dominant Black allele will only express his base coat color, which is determined by the B-Locus and E-Locus. He will not express any colors that occur from the agouti gene, such as "black and tan" or "tricolor."

The second allele is known as the "brindling" allele, and is represented as "Kbr." The Kbr allele is a separate mutation that still allows the agouti gene to be expressed, however, causes brindling of the agouti patterns. The agouti gene represents several different colors, such as fawn/sable, tricolor, tan points, or recessive black.The Kbr allele is recessive to the KB allele, however, it is dominant over a third allele, Ky. Thus, for a dog to express the brindle pattern, he must be either Kbr/Kbr or Kbr/Ky. Dogs that are KB/Kbr will not appear brindle, but can still pass on that allele and potentially produce brindle offspring.

The third allele is represented as "Ky." This allele allows the agouti gene to be expressed without brindling. When a dog is Ky/Ky at the K-locus, the agouti locus determines the dog's coat color. For example, a dog that is Ay/Ay at the agouti locus could be fawn/sable. If that same dog is KB/KB at the K-locus, the agouti locus will be hidden, and his coloration will be determined at the B- and E- loci. However, if that same dog is Ky/Ky at the K-locus, he will then be able to express agouti, and will be fawn/sable.

At this time, there is no direct test for the "Kbr" allele, although it can generally be inferred through testing for the presence of the Dominant Black allele, as well as through phenotypes of the parents and offspring. Testing for the Dominant Black mutation determines if the dog is able to express agouti phenotypes, however, it is limited in that it will not tell you if the dog will be brindled.


K Locus Testing:
Animal Genetics currently offers a test for the K-Locus to determine how many copies of the dominant "KB" allele a dog carries.

Dogs can be DNA tested at ANY age.

Sample Type:
Animal Genetics accepts Buccal Swab, Blood, and Dewclaw samples for testing. Sample collection kits are available and can be ordered at Test Now.


Testing is Relevant For The Following Breeds:
All Breeds.


Results:
Animal Genetics offers DNA testing for dominant KB allele. The genetic test verifies the presence of the dominant mutation and presents results as one of the following:

KB-Allele Results:
KB/KB - The dog carries two copies of the dominant "KB" allele. The dog will be not be brindled or express his agouti phenotype. The dog will always pass on a copy of the "KB" allele to all offspring.
KB/n - One copy of the dominant black allele was detected. The dog will be dominant black, and will not express his agouti phenotype. The dog could pass on this allele, or either the brindle or fawn allele, to any offspring.
n/n - The dog does not carry the dominant black mutation. The dog's coat color will be determined by the agouti gene, and may be brindled or not brindled.


To Submit a Sample For Testing:
Please download a submission form, or order canine sample collection kits at Test Now.


Mail samples to:
Animal Genetics UK,
PO BOX 107, Truro,
Cornwall, England.
TR1 2YR.



Animal Genetics UK
COLOUR & GENETIC TRAITS:
A-Locus (Fawn/Sable Allele)
A-Locus (Recessive Black Allele)
B-Locus (Black/Brown)
D-Locus (Dilution)
E-Locus (Recessive Yellow Allele)
E-Locus (Melanistic Mask Allele)
K-Locus
Hair Curl
Hair Furnishings
Hair Length
Bobtail Gene / Short Tail

CANINE GENETIC DISEASES:
CLAD - Canine Leukocyte Adhesion Deficiency
CD - Cone Degeneration
CNM - Centronuclear Myopathy
Canine Cystinuria
DM - Degenerative Myelopathy
Gray Collie Syndrome - Cyclic Neutropenia
EIC - Exercise-Induced Collapse
FVII - Factor VII Deficiency
CF - Canine Fucosidosis
HC - Hereditary Cataracts
NEwS - Neonatal Encephalopathy with Seizures
MDR1 - Multi-drug Resistance
MLS - Musladin-Lueke Syndrome
PFKD - Phosphofructokinase Deficiency
PRA - Cord1-PRA
PRA - Dominant PRA
PRA - rcd1-PRA
PRA - rcd3-PRA
PLL - Primary Lens Luxation
TNS - Trapped Neutrophil Syndrome
vWD Type1

DNA TYPING SERVICES:
DNA Profile
Parentage Testing

CANINE INFECTIOUS DISEASES:
Canine herpesvirus 1 (CHV-1)
Canine Adenovirus

OTHER SERVICES:
Bird Rings
"Buddy" Digital Egg Monitor
Avian Testing
Equine Testing
Feline Testing
Sheep Testing
Equine Coat Color Calculator
Pricing: 45.00 per test (inclusive of tax, certification included free of charge)
Turnaround time: 5-7 business days.
Results: Phoned, faxed or e-mailed. Testing certificate dispatched after conclusion of test.